半胱胺引起绵羊外周血液β－内啡肽和几种主要代谢激素的变化

CYSTEAMINE INDUCED CHANGES OF β-ENDOPHIN AND METABOLIC HORMONES CONCENTRATION IN THE PERIPHERAL BLOOD OF SHEEP

在４头装置长久性胃肠道瘘管和临时性颈静脉血管插管公绵羊研究表明，经十二指肠瘘管灌注半胱胺（８０ｍｇ／ｋｇ体重）后５ｄ内外周血液的血浆ＳＳ浓度降低３３．６８％（２３３．１±４．４ｐｇ／ｍｌ对１５４．６±＋５．２ｐｇ／ｍｌ，Ｐ＜０．０１）；胃泌素水平升高２３．９％（Ｐ＜０．０５），ＧＨ、胰岛素分别升高１２４．２％（Ｐ＜０．０１）和１４４．０８％（Ｐ＜０．０１）；Ｔ３、Ｔ４水平分别增加７１．８％（ｐ＜０．０１）和１７．５５％（Ｐ＜０．０５）；β－ＥＮＤ水平第３天升高５８．１１％（５７．２９±１．６９ｐｇ／ｍｌ对３２．４４±２．５０ｐｇ／ｍｌ，Ｐ＜０．０１），第５天回落（Ｐ＜０．ｍ）。本实验证明半胱胺可抑制反刍动物ＳＳ水平，使外周血液ＧＨ、胃泌素、胰岛素、Ｔ_３、Ｔ_４和β－ＥＮＤ水平均相应升高，提示促进了反刍动物的消化代谢水平。

Four Hu ram fitted with chronic rumen and duodenal cannulas and temporarycatheter implanted into juglar vein were used in this study.After cvsteamine(CS)infusedinto duodenum, the plasma somatostatin(SS)concentration decreased by 33.8%(233.1±4.4pg/ml vs 154.6±5.2pg/ml),whereas the plasma contents of gastrin,GH andinsulin elevated 23.9%(P<0.05),124.2%(P<0.01)and 144.08%(P<0.01)respe-ctively as compared with control.In addition,blood T3 and T4 levels incresed by 71.8%(P<0.01)and 15.55%(P<0.05),β-END increased by 58.11% at 3rd day,thendecreased at 5th day after CS administration,This study demonstrates that cysteamineinhibits body SS Ievel,thereby,increases the GH,gastrin,insulin,T3,T4 and β-ENDcontents.In results accelerates tlie digestion and metabolism in ruminants.