鼻咽癌雌孕激素受体表达与远处转移的相关性

Relationship between the expression of estrogen and progestrogen receptors in distant metastasis of nasopharyngeal carcinoma

目的:探索雌孕激素受体———雌激素受体(ER)和孕酮受体(PR)表达与鼻咽癌远处转移的相关性,为预后判断提供参考指标。方法:用免疫组织化学SP法检测81例鼻咽癌患者的组织标本。结果:①ER和PR在鼻咽癌组织中的阳性表达率分别为35.8%和53.1%;②PR在T分期中其表达强度有统计学意义(P<0.01),PR在Ⅳb阳性表达率和表达强度均明显高于其他各期(均P<0.01);③ER和PR在远处转移患者(包括放疗前和放疗后)中的阳性表达率均明显高于放疗后无瘤生存5年以上患者(P<0.01和P<0.05)。结论:鼻咽癌组织中ER和PR阳性表达与远处转移呈正相关,阳性表达尤其强阳性者提示预后不良。内分泌治疗有可能减少或推迟远处转移的发生。

Objective：To explore the relationship between the expression of estrogen and progestogen receptors（ER/PR） in distant metastasis of nasopharyngeal carcinoma （NPC）. Method：The expression of ER/PR were detected with immunohistochemical SP method in 81 nasopharyngeal carcinoma who had been treated and followedup. Result：① The positive rates of ER and PR in the tissue of NPC were 35.8% and 53.1%. ②The expression intensity of PR in T stage has obvious statistically significance （ P 〈0.01） , the expression intensity and positive rates of ER in Ⅳb stage were obviously higher than the other stage（ P 〈0.01）. ③The positive rates of ER and PR in patients of the distant metastasis group （including the distant metastasis found before and after radiotherapy） were obviously higher than the group who have been alive with no evidence of disease for five or more than five years after radiotherapy（ P 〈0.01 and P 〈0.05）. Conclusion：The positive expression of ER and PR in NPC were well correlated with the distant metastasis, and it increased gradually. Positive expression, especially the strong positive expression points out the bad prognosis. Endocrine treat may reduce and postpone the distant metastasis.