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ERK信号蛋白在乳腺导管上皮癌变过程中的表达 被引量：1

Research on the expression of ERK protein in the process of canceration of mammary duct
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摘要 目的检测细胞外信号调节激酶(ERK)信号蛋白在人乳腺癌和乳腺增生症组织中的表达,探讨ERK在乳腺导管上皮细胞癌变过程中的作用。方法采用免疫组织化学S-P法,检测67例乳腺组织中ERK信号蛋白的表达。结果ERK信号蛋白在乳腺导管单纯性增生组织中呈弱表达,阳性率为25%(2/8),35例乳腺导管不典型增生中26例ERK阳性表达,阳性率为74.3%(P<0.05)。24例乳腺癌组织中22例ERK阳性表达,阳性率为91.6%,与增生组比较有显著差异(P<0.05)。结论ERK信号蛋白在乳腺癌的组织发生中起关键作用,其表达强度与乳腺导管上皮的恶性转化有关。
作者 李栢林 王辉 赵艳 王睿 宋敏 宋继谒
机构地区 中国医科大学基础医学院化学教研室 中国医科大学基础医学院病理学教研室
出处 《中国老年学杂志》 CAS CSCD 北大核心 2006年第5期673-675,共3页 Chinese Journal of Gerontology
基金 辽宁省教育厅科研项目(No.2004D107)
关键词 细胞外信号调节激酶 乳腺导管不典型增生 乳腺癌 免疫组织化学
分类号 R737.9 [医药卫生—肿瘤]
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参考文献8

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同被引文献14

  • 1马萍,李柏林,张英,宋敏,宋继谒.ERK PI3-K在乳腺癌及癌前组织中的表达及相关性[J].中国肿瘤临床,2006,33(14):805-807. 被引量：4
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  • 10Chen CL,Lin CF,Chang WT,et al. Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin- interacting protein-mediated pathway [ J ]. Blood, 2008,111 ( 8 ) :4365- 4374.

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中国老年学杂志
2006年 第5期

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