羟基喜树碱联合力尔凡治疗恶性胸腹水临床观察

Hydroxycamptothecin Combining with Lifein In Treatment Of Malignant Pleural And Petitoneal Effusion

目的探讨羟基喜树碱联合力尔凡腔内化疗治疗恶性胸腹水的临床疗效。方法对经影像学检查及病例细胞学证实为癌症所致恶性胸腹水的30例患者尽量抽取胸腹水后,注入羟基喜树碱20mg,力尔凡30mg,每周1次,共3～4周。结果CR5例,PR18例,近期有效率为了76.7%,不良反应轻微。结论羟基喜树碱联合力尔凡治疗恶性胸腹水有协同作用,能增强患者的细胞免疫功能,同时减少恶性胸腹水,提高晚期癌症患者的生存质量。

Objectice To evaluate the clinical efficacy and toxicity of llydroxycamptothecin combining with Lifein in treatment of malignant peural and peritoneal effusion, thirty cases were considered. Methods The patients were extracted pleural and peritoneal effusion then injected Hydroxycamptothecin 20mg and Lifein30mg ocea week and above all for three to four weeks. Results Complete remission （CR） for five cases and partial remission （PR） for eighteen cases. The total, effective rates were 76.7%. Conclusion It has synergetic effect when combine the Hydroxycamptothecin and Lifein to treat malignant pleural and peritoneal effusion. It can improve the cell immune of the body, decrease malignant pleural and peritoneal effusion and improve the improve the quality life.