慢性乙型肝炎患者血清HA、LN、ⅣC及PⅢNP含量与肝纤维化程度的关系探讨

The Relationship between the Levels of Serum HA、LN、ⅣC and PⅢNP of Chronic Hepatitis and Indexes of Live Fibrosis

目的探讨慢性乙型肝炎(以下简称慢性乙肝)患者血清的肝纤维化程度与血清透明质酸(HA)、层粘连蛋白(LN)、Ⅳ型胶原(ⅣC)及Ⅲ型前胶原氨端肽(PⅢNP)含量的关系。方法用放射免疫法检测439例慢性乙肝患者血清HA、LN、ⅣC及PⅢNP的含量,同时结合临床特点、病理切片等,运用统计学方法对上述血清学指标的诊断价值进行分析。结果慢性乙肝轻、中、重度及肝硬化患者血清HA、LN、ⅣC及PⅢNP水平均不同程度高于正常对照组(P<0.05或P<0.01)。肝硬化患者随着Child-Pugh分级的增加(A级到C级),血清HA、LN、ⅣC及PⅢNP含量均逐渐增加,且不同级别间有显著性差异(P<0.01)。结论上述四项肝纤维化血清学指标的检测能在一定程度上反映肝纤维化的进展情况,对慢性乙肝患者肝纤维化的诊断有重要意义。

Objective To study the relationship between the levels of serum HA, LN, ⅣC, PⅢNP of chronic hepatitis and indexes of live fibrosis. Methods The levels of serum HA, LN, ⅣC and PⅢNP of chrouic hepatitis of 439 cases were measured by radio immunoassay, combined with clinical characteristics and pathologic slice etc. The diagnostic significance of the indexes of serum was analyzed with ststistics. Results The value of HA, LN,ⅣC and PⅢNP in the chronic hepatitis group was significantly higher than that in the normal comparative group （P〈 0.05 or P〈 0.01）.The levels of HA, LN, ⅣC and PⅢNP increased gradually with live cirrhosis graded as Child-Pugh A-B and C. And the difference is apparent among the different grades （P〈 0.01）.Conclusions The levels of serum HA, LN, ⅣC and PⅢNP are in concert with the degree of liver fibrosis, and these indexes are valuable for chronic hepatitis diagnoses Combined with the clinics.