精氨酸甘草次酸的制备及核磁共振谱分析

Study on Preparation of Arginine-Glycyrrhetinic Acid and Structure Analysis by 1D and 2D Spectra of Nuclear Magnetic Resonance

以18β-甘草次酸为原料,合成了一种新的甘草次酸盐类衍生物——精氨酸甘草次酸,利用1HNMR、13CNMR、DEPT、1H-1HCOSY、HMQC、HMBC等1D和2DNMR技术对其碳和氢质子信号进行了全归属,并通过与两种原料化合物核磁共振谱数据的对比,揭示了该成盐反应的作用机制和产物的结构类型。

A new derivative of glycyrrhetinic acid, arginine-glycyrrhetinic acid, was synthesized by the reaction of 18β-glycyrrhetinic acid with L-arginine. ^1H NMR （nuclear magnetic resonance）, ^13C NMR, distorsionless enhancement by polarization transter （DEPT） and a series of 2D NMR techniques, including heteronuclear multiple quantrum correlation （HMQC）, heteronuclear multiple bond correlation （HMBC） and ^1H-^1H correlation spectrometry （COSY）, were applied to assign all carbon and proton signals of the product. Moreover, the mechanism of this reaction and the bond type yielded between the two reactants were studied by comparing the NMR data of product and those of reactants.