尼莫地平、维拉帕米、卡托普利及普罗布可的体外抑制脂质过氧化作用

Inhabitive Effects of Nimodipine,Verapamil,Captopril and Probucol on LDL Peroxidation in vitro

目的：研究钙拮抗剂、抗氧化剂及转换酶抑制剂抗动脉粥样硬化作用的机理。方法：以体外铜离子催化的ＬＤＬ脂质过氧化时硫代巴比妥酸反应物质（ＴＢＡＲＳ）为指标。结果：尼莫地平、维拉帕米、卡托普利及普罗布可均有程度不同的抑制ＴＢＡＲＳ生成的作用，抑制ＴＢＡＲＳ５０％生成量所需的浓度分别为５３、３１５、３４４、３．３μｍｏｌ／Ｌ。结论：上述药物抑制脂质过氧化的作用可能是抗动脉粥样硬化的主要机制之一。

OBJECTIVES:In order to investigate the antiatherogenic mechanisms of calcium antagonists,antioxidatants and ACE-I. METHODS:Effects of these drugs on TBARS production during theLDL peroxidation by copper in vitro were compared. RESULTS: It is suggested that Nimodipine,Probucol,captopril and DTPA inhabit the LDL peroxidation in bitro, concentrations required forreducing 50% of TBARS production was 53, 315, 344 and 3. 3 μmol/L, respectively.CONCLUSIONS: The inhabitive effect of the drugs studied on LDL peroxidation may contributeto their antiatherogenic properties.