柠檬萜对豚鼠小肠电活动的调整作用

Regulative Effect of R(+)-Limonene on the Small Intesinal Electric Activities of Guinea-Pigs

目的：研究柠檬萜对豚鼠小肠电活动的影响。方法：用电生理技术记录以９８％柠檬萜给空腹清醒豚鼠灌胃后小肠消化间期综合肌电的变化。结果：给柠檬萜后，十二指肠及空肠峰电位明显减少（Ｐ＜０．０１，Ｐ＜０．０５）。原先ＩＤＭＥＣ周期不典型或紊乱的峰电位在给药后４０～８０ｍｉｎ，十二指肠和空肠分别有７６％和８２％例次呈现出典型的ＩＤＭＥＣ周期或有出现ＩＤＭＥＣ周期的倾向。结论：柠檬萜可能具有调整豚鼠小肠电活动周期的作用。

OBJECTIVES:To study the effect of R (+)-Limonene on the small intestinal electric activities of tile guinea-pig. METHODS: The electrophysiological technique was applied to record the variation of small intestinal interdigestive myoelectric complex (IDMEC)after instilling 98% R (+ )-Limonene into the stomach of fasted conscious guinea-pigs. RESULTS: After administration of R (+)-Linonene, the number of spilte potential in duodenum and jejunum was decreased sigllificantly (PRO. of;P<0. 05).The standard cycle of IDMEC and tendency toward stalldard cycle were found in 76% of the duodenum alld 82% of the jejunum that had an unstandard cycle of IDMEC or irregular spike potentiell before drugs. CONCLUSIONS: R (+) -Limonene is suggested to regulate the electric activitiy c ycle in the small intestine of guinea-pigs.