大肠癌浸润的螺旋CT征象与其血管生成研究

Correlation between SCT Features and Tumor Angiogenesis in Colorectal Carcinoma

目的探讨大肠癌浸润转移螺旋CT征象与MVD和VEGF表达间的关系。方法对42例大肠癌病人进行低张水灌肠SCT扫描,术后采用免疫组织化学SP法检测肿瘤组织中VEGF的表达,并计数MVD。结果①在SCT征象上有淋巴结转移和浆膜侵犯组,VEGF的阳性表达显著高于无淋巴结转移和浆膜侵犯组(P<0.05),组间MVD比较差异显著(P<0.05)。②Dukes C+D期VEGF阳性表达和MVD显著高于A期(P<0.05)。③VEGF阳性组的MVD显著高于VEGF阴性组(P<0.05)。结论根据大肠癌浸润转移螺旋CT征象可以在一定程度上反映大肠癌组织中MVD及VEGF的表达。

Objective To study the relation between the expressions of VEGF as well as MVD and SCT features in colorectal carcinoma. Methods Water enema spiral CT were performed in 42 patients with colorectal carcinoma. After operation, all the specimens were used to analyze the MVD as well as the expressions of VEGF by SP method. Results ① In the groups with lymph node metastases and serosa -infiltration and in the groups without lymph node metastases and serosa -infiltration of 42 cases in SCT features, the difference of the VEGF - positive rates were statistically signifi- cant （ P 〈0.05 ）, The difference of the microvessel densities（MVD） were also statistically significant （ P 〈0.05）. ②The positive rate of VEGF protein and MVD in Dukes＇ stage C ＋ D cases were remarkably higher than that in Dukes＇ stage A cases （ P 〈 0, 05 ）. ③The difference between the microvessel densities in the VEGF - positive group and the VEGF - negative group was significant （ P 〈 0.05 ）. Conclusion According to SCT features of invasion and metastasis we can judge MVD and expression of VEGF to a certian extent in colorectal carcinoma.