急性冠脉综合征与金属蛋白酶相关性探讨

Study of Serum Concentration of Matrix Metalloproteinases in Acute Coronary Syndrome

目的 探讨基质金属蛋白酶（MMPs）与急性冠脉综合征粥样斑块破裂之间的相关性。方法 采用随机对照，测定89例不稳定型心绞痛，52例急性心肌梗死患者胸痛发作12-24h内血清基质金属蛋白酶-1（MMP-1），基质金属蛋白酶-9（MMP-9）的水平。另设健康对照组（n=70）与之对照。结果 急性冠脉综合征患者MMP-1，MMP-9水平较健康对照组明显增高（P〈0．01），且心肌梗死组与不稳定型心绞痛组患者比较差异也有显著性（P〈0．01）。结论 血清MMP-1，MMP-9增高与斑块破裂具有密切的相关性。

Objective To Study the relationship of Matrix metalloproteinase （MMPs） and coronary plaque disruption in acute coronary syndromes（ACS）. Methods Detected the concentration of serum Matrix metalloproteinase -9（ MMP- 9 ）and MMP -1 in patients with unstable angina（ UA, n = 89） and acute myocardial infarction （AMI, n = 52 ）. The blood samples were drown from venous in the 12 to 24 hours after episode. Compared the levels of MMP - 1 and MMP -9 with normal control group（ NS, n = 70）. Results The levels of MMP - 1 and MMP -9 in patients with ACS are significant increasing compared with that of control group（ P 〈0.01 ） ,and AMI group shows a much higher concentration of MMP - 1 and MMP - 9 than those of UA group, too. （ P 〈 0.01 ）. Conclusion Serum concentrations of MMP -9 and MMP - 1 have a preferable relation with plaque disruption.