组织学分级相同而预后不同的食管癌生物学特性的比较研究

Comparison Study of Biological Characteristics Between Esophageal Carcinoma with Similar Grades and Unsimilar Prognosis

８０例食管癌标本被分为＜１年组（术后生存１２月＞１０月）和≥５年组。两组各合分化Ⅰ级者１３例、Ⅱ级１３例，Ⅲ级１４例。应用病理学方法和流式细胞术对两组标本的生物学特性进行了比较研究。结果显示，＜１年组中的侵及外膜、淋巴结转移和倍体异质性肿瘤的病例显著高于≥５年组（Ｐ＜０．０５～０．０２５）。本文认为上述指标可作为组织学分级的有用参数。

Eighty cases of specimens of the esophageal squamous cell carcinoma were divided into two groups: <1-year group in which patients survived for 12 months>10 months after operation,and≥5-year group. There were 13 cases with grade Ⅰ, 13 with grade Ⅱ and 14 with grade Ⅲ in each group. The biological characteristics were compared between the two groups by means of pathological method and flow cytometry (FCM).The results showed that cases of invading seromembrane,lymphatic metastasis and ploid heterogeneous tumor (PHT) in<1-year group were significantly more than those in≥5-year group. The present study shows that the indexes mentioned can be considered as a useful helper for histological grading of esophageal carcinoma.