新药炎琥宁的碳氢NMR信号全归属(英文)

Assignment of ^(13)C and()~1H Chemical Shifts of Potassium Sodium Dehydroandrographolide Succinate

炎琥宁为中药提取物穿心莲内酯经结构改造后获得的一个抗菌、抗病毒新药,本文应用1D NMR和脉冲梯度场2D NMR实验技术(gCOSY,gHSQC,gHSQC-TO-COSY,gHMBC)对其结构进行了研究,并首次对其1H NMR、13C NMR谱信号进行了全归属.

Potassium sodium dehydroandrographolide succinate （PSDS） is a new antibacterial and antiviral agent derived from andrographolide, a compound found in the extract of medicina[ herb Andrographis panlculata （Burm. f. ） Nees. In this study, the ^ 13C and ^1H chemical shifts of the compound were assigned using 1D NMR and 2D NMR techniques including gCOSY, gHSQC, gHSQC-TOCOSY and gHMBC. Its structure was determined from the NMR data.