聚乙二醇类的生物降解

BIODEGRADATION OF POLYETHYLENE GLYCOLS

本文对聚乙二醇的生物降解研究进行了评述．聚乙二醇的降解性能取决于分子量的大小，分子量较高的降解不佳．聚乙二醇的好氧代谢作用机理已较清楚：首先被氧化成乙醛和一元羧酸，进一步进行解聚；但其厌氧代谢作用机理沿不明确，已提出的许多机理还有待进一步研究确证．

Biodegradation of polyethylene glycols(PEG)is reveiwed in this paper. The degradability of PEGs depends on the molecular weight. Higher !nolecular weight results in poor degradation. Aerobic metabolism of PEGs is clear= first oxidized to an aldehyde and rnonocarboxylic acid,then followed by dcpolymerizatiotl. On the other hand,the mechanism of anaerobic metabolism is still not clear,rnosl of the proposed mechanisms need to be firmed.