小剂量米非司酮用于紧急避孕的临床观察

Observation clinical science of low——dose mifepristone for emergency contraception

目的探讨一次性小剂量米非司酮25mg用于紧急避孕的效果及可接受性。方法无保护性交或避孕措施失效后72小时内来院就诊的健康妇女50例单次口服米非司酮25mg,服药后按时随访并观察药物副反应及下次月经情况,保证月经复潮前禁欲或采用避孕套避孕。结果根据Dixon方法计算预期妊娠数为4.850,实际妊娠数为1例,避孕有效率为79.4%实际妊娠与预期妊娠相比有显著差异(P<0.05)。结论小剂量米非司酮用于紧急避孕是非常简便、安全、有效的方法。

Objective To evaluate the effectiveness and acceptability of low-dose mifepristone 25mg as an emergency postcoital contraception. Methods We have studied requesting emergency contraception 50 women who have had unprocted intercourse or contraception failures. They were given mifepristone with a single dose of 25mg within 72 hours after the intercourse and were told to follow-up survey on time.The effect of drug and the next menstruation were observed. Results According to the method of Dixon,the expected pregnancys was 4.850,while 1 pregnancy really occurred and there was a significant （P〈0.05） difference between expected pregnancies and raw pregnancies. The effective rate of contraception was 79.4%.Conclusion Mifepristone of 25mg for emergency contraception is a very simple,safe and effective method.