西酞普兰与帕罗西汀治疗抑郁症的临床研究

A Comparative study of citalopram and Paroxetine in the treatment of depression

目的:比较西酞普兰与帕罗西汀治疗抑郁症的疗效及安全性。方法:82例符合CCMD-3抑郁症诊断标准的患者,随机分配用西酞普兰和帕罗西汀治疗,疗程6周,用汉密尔顿抑郁量表(HAMD)评定临床疗效,副反应量表(TESS)评定不良反应。结果:西酞普兰组显效率63.4%,有效率83%,帕罗西汀组为63.4%;78%,疗效相当,差异无显著性。两组不良反应轻微。结论:西酞普兰和帕罗西汀抗抑郁疗效肯定,不良反应轻。

Objective：To compare the efficacy and side effects of citalopram and Paroxetine in the treatment of depression. Methods ：82 patients who met CCMD -3 criteria for depression were randomly assigned to citalopram group and Paroxetine group. The Period of study was 6 weeks. The efficacy was rated with Hamilton Depression Rating Scale（HAMD） ,and the side effects were rated with Treatmend Emergent symptoms scale （TESS）. Results： Total clinical effective rate and response rate Was 63.4% and 83% for Citalopram group, 63.4% and 78% for Paroxetine group after 6 Weeks repectively. There Were no significant differences on clinical efficacy between 2 groups. Conclusions： Citalopram and Paroxetine is effective antidepressants with fewer side effects.