CD_(105)及肿瘤组织微血管密度与膀胱移行细胞癌的关系

Study on the correlation of the expressions of CD_(105) and the microvessel density in transitional cell carcinoma of the bladder

目的:检测CD105在膀胱移行细胞癌组织中的表达及微血管密度,探讨CD105在膀胱移行细胞癌发生、发展、浸润和转移中的作用及相互关系。方法:采用免疫组织化学SP法测定6例膀胱乳头状瘤,30例膀胱移行细胞癌组织CD105的表达及M VD。结果:CD105蛋白在膀胱移行细胞癌无淋巴结转移组和淋巴结转移组中的阳性表达率分别为80%和100%,微血管密度值分别为26.9±5.8和31.7±4.3,两组比较,差异有统计学意义(P<0.05)。CD105蛋白在膀胱移行细胞癌无明显浸润组和浸润组中的阳性表达率分别为47%和82%,微血管密度值分别为21.4±3.6和28.4±4.7,两组比较,差异有统计学意义(P<0.05)。结论:CD105蛋白阳性表达及微血管密度值的高低与膀胱移行细胞癌发生、发展、浸润和转移有关。

Objective To study the expression of CD105 and the microvessel density in the transitional cell carcinoma of the bladder and discuss their correlation in the pathogenesis,development, invasion and metastasis in transitional cell carcinoma of the bladder tissues. Methods Immunohistoehemistry SP method was used to detect the expression and microvessel density of CD105 in 6 tissues of bladder papilloma and in 30 tissues of primary transitional cell carcinoma of bladder.Results The rates of positive expressions of CD105 protein in the tissue of non-metastasis and metastasis were 82%（10/12） and 88%（16/18） respectively. The difference in the two groups had a statistical significance （P〈0. 05）. The rates of positive expressions of CD105 protein in the tissue of non-invasion and invasion were 48 % （9/19） and 80 % （14/17） respectively. The difference in the two groups had a statistical significance （P 〈0. 05）. Conclusion The over expression of CD105 and microvessel density in transitional cell carcinoma of the bladder is related to pathogenesis,development, invasion and metastasis of transitional cell carcinoma of the bladder.