伪狂犬病病毒囊膜蛋白gD研究进展

Progress on Envelope Glycoprotein D of Pseudorabies virus

伪狂犬病是目前危害养猪业最主要的传染病之一,虽然一些国家实施了根除计划,但在绝大多数国家,尤其是发展中国家,该病仍然频繁发生,造成的经济损失巨大,严重制约着这些国家和地区养殖业的发展。成熟的伪狂犬病病毒粒子约有50种蛋白质,包括各种糖蛋白。其中,已有10种糖蛋白被鉴定,并分别命名为gB、gC、gD、gE、gH、gI、gK、gL,gM和gN。他们在病毒与细胞的相互作用,病毒感染的病理过程和免疫原性中各具特殊作用。囊膜糖蛋白gD是病毒最主要的免疫原性成分之一,在病毒的感染和增殖过程中具有重要作用。研究其基因组和蛋白结构对伪狂犬病的防控具有重要的意义。

Pseudorabies（PR） is a serious illness of swine and causes significant financial losses in the pig industry. The ripe virus contains about 50 kinds of proteins in which 11 kinds of glycoproteins were identified and named gB, gC, gD, gE, gF, gH, gI, gK, gL, gM and gN, respectively. These glycoproteins take a particuliar role in the interaction between the virus and cell, the pathological process of the virus infection, and the production of immunogenicity. Glycoprotein D （gD）,the most important immunogenicity indegrent, take an important part in the process of the virus infection and the hyperplasia,therefore, There was significant value to reseaching its genes and protein structure in the prophylaxis of the pseudorabies.