摘要
目的:研究心律泰对离体豚鼠乳头肌动作电位的影响。方法:采用标准微电极细胞内记录技术。结果:心律泰呈浓度依赖性地降低离体豚鼠乳头肌动作电位(AP)的Vmax、APA,缩短APD20、APD50、APD90。中浓度时(4 mg生药／ml),使Vmax, APA,APD20,APD50,APD90由给药前的122．6±25．4 v／s,98．0±10．8 mv,114．4±16．7 ms,174．7±25．0 ms,250．4±39．2 ms分别降为115．9±25．4 v／s,89．7±11．2 mv,107．7±14．8 ms,164．9±26．7 ms,234．4±39．4 ms,心律泰对RP无影响。结论:心律泰抗心律失常的可能机制与抑制Na+,Ca2+内流、促进K+外流有关。
Objective： To investigate the effects of Xinlvtai on action potential of ventricular papillary muscles in isolated guinea pig. Method： Standard mieroelectrode intracellular recording technique was used. Result： Xirdvtai decreased APA and slope of Vmax, shortened 20% APD（ APD20 ） ,50% APD（ APD50 ） and 90% APD（APD90 ） in concentration-dependent manner. It had no significant effect on RP of AP. Conclusion： It was supposed that its mechanism of action was associated with blocking sodium ion and calcium ion influx, promoting potassium ion outflux.
出处
《中国药师》
CAS
2006年第6期488-490,共3页
China Pharmacist
基金
湖北省重点科技攻关项目(No.983131)
