正交设计优选冰片β-环糊精包合物的制备工艺

Optimization of Preparative Process of Borneol-β-Cyclodextrin Inclusion Compound with Orthogonal Design

目的:研究β-环糊精包合冰片的最佳工艺。方法:采用正交实验设计,以包合率和包合物收率为指标评价包合工艺。结果:优选出包合物工艺为,冰片与β-环糊精重量比为1:6,包合温度为60℃,包合时间为1 h。结论:此工艺简单,稳定,包合率和包合物收率高,适于工业化生产。

Objective： To study the preparation of borneol-β-cyclodextrin inclusion compound. Method： It was studied with orthogonal design, the inclusion rate of borneol and yield of inclusion compound were used as criteria in the test. Result： The best way to prepare inclusion compound was as follow： the weight ratio between borneol and β-CD is 1：6, temperature is 60℃, reaction time is 1 h. Conclusion： This method is simple, stable . The inclusion rate of bemeol and the yield of inclusion compound are higher. It can be used for the production in industry.