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上海市中小学女生CYP3A酶活性分析 被引量：3

Study on Activity of CYP3A of Female Students in Shanghai
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摘要 目的:分析女中小学生CYP3A酶活性及其变化趋势。方法:用HPLC梯度洗脱法测定573名女中小学生尿液中6β-羟基氢化可的松和氢化可的松的含量,并通过计算其比值分析CYP3A的活性。结果:在青春期开始发育时CYP3A酶的活性降低,且发育后酶活性个体差异变大。结论:中小学女生年龄跨越大,临床使用经CYP3A酶代谢的药物时应根据身体发育情况适当调整。 Objective： To study the variety of the activity of the Cytochrome P450 3A（CYP3A） of the female students in Shanghai and its trend. Method： The concentration of 6β-hydroxycortisol and cortisol in urinary was determined by HPLC ,and the variety of the activity of CYP3A and its trend were analyzed hy the 6β-hydroxycortisol-cortisol ratio. Result： the activity of the CYP3A fails and the coefficient of variation becomes larger when students begin to come into adolescence. Conclusion： The drugs metabolized by CYP3A should be properly adjusted according to developmental status of the students.
作者 刘海涛 唐跃年 张健 陈伦
机构地区 上海第二医科大学附属新华医院
出处 《中国药师》 CAS 2006年第6期521-522,共2页 China Pharmacist
关键词 6β-羟基氢化可的松 氢化可的松 CYP3A酶 活性 6β-hydroxy-hydrocortisone Hydrocortisone CYP3A Activity
分类号 Q55 [生物学—生物化学]
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参考文献8

  • 1Ophelia,Shi X.J, Tomlinson B, et al. Interindividual and Intraindividual Variability of the Urinary 6β-hydroxycortisol/cortisol Ratio in Chinese Subjects:Implications of Its Use for Evaluating CYP3A Activity [J]. Journal of Clinical Pharmacology, 2004,44:1412-1417
  • 2陈娜,姚兵.高效液相梯度洗脱法测定血清中氢化可的松和可的松的含量[J].徐州医学院学报,2003,23(2):107-110. 被引量：6
  • 3徐月萍.细胞色素P450酶系与药物代谢的相互作用[J].中国药物与临床,2003,3(2):141-143. 被引量：14
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二级参考文献7

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共引文献16

同被引文献23

引证文献3

二级引证文献15

中国药师
2006年 第6期

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