摘要
目的:探讨复方葡萄籽提取物(GSE)对化学性肝损伤的预防和治疗作用。方法:用小鼠建造四氯化碳肝损伤和乙醇肝损伤模型,观察乙醇灌胃前预先给予复方GSE及乙醇或四氯化碳灌胃后再给予复方GSE后小鼠血清谷丙转氨酶(ALT),肝细胞超氧化物歧化酶(SOD)、谷光甘肽(GSH)、丙二醛(MDA)。结果:预先给予GSE可增强SOD活性,防止乙醇导致的肝GSH减少,有效降低小鼠血清ALT和肝细胞MDA上升程度,在乙醇或四氯化碳灌胃后再给予复方GSE,也可降低小鼠血清中ALT和肝细胞脂质过氧化产物。结论:复方GSE对乙醇肝损伤有预防和治疗作用。对四氯化碳肝损伤也有一定治疗作用。
Objective：To explore the preventive and therapeutic effects of compound grape seeds extracts （GSE） on chemical liver injury. Methods： The mice were treated with GSE followed by ethanol or tetrachlormethane administration （by gastric intubation）. Then, serum ALT, SOD activities and GSH, MDA contents were detected. and MDA contents significantly decreased in GSE group. After ethanol or tetrachlormethane administration, both ALT activites and MDA contents in GSE group decreased. Conclusion：GSE has either preventive effects on ethanol-induced liver injury or therapeutic effects on tetrachlormethane -induced liver injury.
出处
《西北国防医学杂志》
CAS
2006年第3期176-178,共3页
Medical Journal of National Defending Forces in Northwest China
基金
甘肃省自然科学基金暨中青年科技基金资助项目(ZS011-A25-78-Y)
关键词
肝损伤
葡萄籽提取物
乙醇
四氯化碳
Liver injury
Grape seeds extracts
Ethanol
Tetrachlormethane
