摘要
目的:通过研究下呼吸道细菌感染患者的头孢丙烯临床药代动力学参数,为临床选择合理给药方案提供依据。方法:用HPLC法测定10例下呼吸道细菌感染患者连续给药5d后的稳态血药浓度,数据用3P97 药物动力学模拟系统处理。结果:头孢丙烯的药时曲线符合二室开放模型,主要药代动力学参数:t1/2为 (1.55±0.17)h,MRT为(2.52±0.15)h,Cmax为(13.32±1.28)μg/mL,tmax为(1.41±0.31)h,AUC0-10为 (31.68±7.68)μg h/mL。结论:口服头孢丙烯片500mg,每天2次,能获得控制下呼吸道细菌感染的有效治疗浓度。
Objective:To offer the evidence for reasonable dosage regimen by the pharmacokineties study of cefprozil in patients with low respiratory tract hacterial infections. Methods:The cefprozil concentration in plasma was determined by the high performance liquid chromatography method, The pharmaeokinetic parameters were obtained by using 3P97 imitate program. Results:With oral multipie - dose of 500mg of cefprozil twice over 5 consecutive days, the main pharmacokinetic parameters obtained from the patients were as follows:t1/2 was ( 1.55 ±0.17)h ,MRT was (2.52 ±0.15) h,Cmax , was ( 13.32 ± 1.28) μg/mL,t was ( 1.41 ±0.31 )h ,AUC0-10 was ( 31.68 ± 7.68) μg · h/mL. Conclusions: Conclusions 500mg, hid orally may be effective against low respiratory tract bacterial infect infcctions.
出处
《药学实践杂志》
CAS
2006年第3期144-146,共3页
Journal of Pharmaceutical Practice