1,4-二氧喹喔啉甲醛亚胺的合成和抑菌活性

Synthesis and Bacteriostatic Activity of 1,4-Dioxide Quinoxaline Formaldehyde Imine

用1，4-二氧喹喔啉甲醛与氨基脲、苯胺、取代苯胺等反应，合成了11种1，4-二氧喹喔啉甲醛．缩氨脲和醛亚胺。用元素分析、MS、IR和NMR测试技术对这些新化合物的结构进行了表征；测试了这些新化合物对5种真菌的抑菌活性。结果表明，1，4-二氧喹喔啉甲醛-缩氨脲在80mg／L浓度时的抑制率在20％以下；一般1，4-二氧喹喔啉甲醛亚胺在80mg／L浓度时抑制率在30％～40％；双醛亚胺基本没有抑菌活性，苯环邻位具有推电子基的醛亚胺g和h的抑制率可以达到50％-60％。

1,4-dioxide quinoxaline formaldehyde semicarbazones and imines were synthesized by the reactions of 1,4-dioxide quinoxaline formaldehyde with aminourea or substituted anilines. The structures were characterized by IR, MS, H NMR and elemental analysis. The bacteriostatic activities of the new compounds were assessed by 5 fungies. The results are as follow： the bacteriostatic effects of semicarbazones and formaldehyde imines are below 20% and in the range of 30% -40% at a dosage of 80 mg/L, di-aldehydethe imines have no effect, while those of formaldehyde imines g and h having o-electron donating group substituted anilines can reach 50% or higher.