头电针对帕金森病患者纹状体区DAT显像影响

Effect of electro-scalp acupuncture on cerebral dopamine transporter in the striatum area of the patient of Parkinson's disease by means of single photon emission computer tomography

目的:运用SPECT技术探讨头电针治疗帕金森病(PD)的机理。方法:5例PD患者均接受顶颞前斜线(MS6),额旁3线(MS4),顶旁1线(MS8),顶旁2线(MS9),枕下旁线(MS14)的电针治疗,单侧病变针对侧,双侧病变针双侧。治疗前后分别行99mTc-TRODAT-1SPECT显像,利用感兴趣区(ROI)测定纹状体/枕叶(ST/OC)的比值,分析纹状体区的多巴胺转运体(DAT)活性。结果:治疗前后发病同侧ST/OC分别是1·19±0·15和1·24±0·31,而对侧分别是0·90±0·12和0·95±0·25,治疗后均有增加,但差异无统计学意义(P>0·05)。结论:头电针可以减少PD患者纹状体区DAT的丢失,改善纹状体区DAT的活性。

Objective To probe the mechanism of electro-scalp acupuncture in treatment of Parkinson＇s disease （PD） by single photon emission computer tomography （SPECT）. Methods Five cases of PD received electro-scalp acupuncture at Dingnie Qianxiexian （MS 6）, Epangxian Ⅲ（MS 4）, Dingpangxian I （MS 81, Dingpangxian Ⅱ（MS 91 and Zhenxia Pangxian （MS 14） Contralateral points were selected for pathologic change on one side and bilateral points were selected for pathologic lesion on both sides. All the patients received 99mTc-TRODAT-1 SPECT examination before and after acupuncture treatment of 6 weeks. And activities of dopamine transporter （DAT/ were analyzed by the ratio of striatum/occipital lobe （ST/OC）, which was evaluated by means of technique of regional of interesting （RO1）. Results The ratio of ST/OC on the same side of the affected extremity before and after treatment were 1.19±0. 15 and 1.24±0.31 respectively. And on the other side were 0. 90±0. 12 and 0.95±0.25 respectively. They were increased after treatment （P〉0. 05）. Conclusion Electro-scalp acupuncture can decrease the loss of DAT and improve the activities of DAT in the striatum of the patient of PD.