曲尼司特对心肌梗死后心肌间质纤维化的影响

Tranilast inhibits myocardial fibrosis after myocardial infarction

目的探讨曲尼司特对兔心肌梗死后心肌间质纤维化干预作用。方法结扎左前降支制作兔心肌梗死模型,分实验组和对照组。3周后经胃管分别给予曲尼司特及安慰剂1月,心脏彩超评价心功能并检测血清转化生长因子(transform ing growth factor,TGF-β1),I、III型胶原浓度及组织羟脯胺酸含量。结果实验组治疗前后心功能、心腔内径、室壁厚度明显改善,血清TGF-β1,I、III型胶原浓度及羟脯胺酸含量较对照组明显下降。结论曲尼司特可有效拮抗心肌梗死后心肌间质纤维化,预防心室重构。

AIM To explore the effect of tranilast on the myocardial fibrosis after myocardial infarction. METHODS The model of myocardial infarction was made on rabbits by ligation of the major ventricular branch of the left coronary artery. Three weeks later, the rabbits were given tranilast or placebo for one month via gastric canal. Heart function was assessed and the levels of TGF-β1, collagen and hydroxyproline were measured. RESULTS Compared with the control, cardiac function, the bore of left ventricule, the concentration of TGF-β1, collagen and hydroxyproline were significantly decreased in tranilast group. CONCLUSION Tranilast effectively inhibis myocardial fibrosis after myocardial infarction and prevents the development of ventricular remodeling.