血尿酸与冠心病的相关分析

Association between serum uric acid and coronary heart disease

目的分析血清尿酸水平是否与冠心病相关。方法经冠状动脉造影确诊的冠心病患者142例和非冠心病患者92例。分别测定血清尿酸及血脂水平,同时记录性别、年龄、吸烟、高血压、糖尿病等相关因素。结果冠心病患者血清尿酸水平显著高于对照组(P<0.01),相关分析显示血清尿酸水平与冠脉狭窄指数、年龄、高血压、糖尿病、高密度脂蛋白、胆固醇(P<0.05或P<0.01)呈正相关。多因素回归分析显示,血清尿酸与冠心病的发生和冠脉狭窄指数无明显相关。结论高尿酸血症不是冠心病的独立危险因素。

AIM To analyze the association of serum uric acid with coronary heart disease （CAD）. METHODS One hundred and forty-two patients with CHD confirmed by angiography and 92 control subjects without CHD were included in this study and serum uric acid and blood lipid were determined. The risk factors of coronary heart disease： gender, age, smoking, hypertension and diabetes mellitus were registered. RESULTS The serum uric acid level in CHD patients was markedly higher than that in control subjects （P 〈0.01 ）. The correlation analysis results showed that the serum uric acid level was positively and significantly related to the coronary stenosis index, age, hypertension, diabetes mellitus, TC and HDL-c （P 〈0.05 or P 〈0.01, respectivetly）. Multivariate Logistic and stepwise regression analysis showed that the serum uric acid was not markedly related with the occurrence of CHD and the coronary stenosis index. CONCLUSION Elevated serum uric acid is not an independent risk factor for CHD.