天螺霜对免疫性肝损伤小鼠血清及肝组织ALT、AST的影响

The Effects of the Polysaccharide from Kiangsinensis on ALT and AST in the Serum and the Liver Tissue of Mice with Immunologic Liver-Injury

目的观察天螺霜对免疫性肝损伤小鼠血清和肝组织丙氨酸转氨酶(ALT)及天冬氨酸转氨酶(AST)的影响。方法建立卡介苗(BCG)加脂多糖(LPS)诱发的免疫性肝损伤模型,测定小鼠血清和肝组织ALT及AST。结果天螺霜使免疫性肝损伤小鼠血清ALT、AST活性显著降低,肝组织ALT、AST活性显者升高。结论天螺霜对小鼠免疫性肝损伤具有保护作用。

Objective:To study the effects of the polysaccharicde from kiangsinensis on the alanine aminotransferase(ALT) adn aspartate aminotransferase(AST) in the serum and liver tisssue of mice with immunologic liver-injury. Methods:Bacillus Calmette-Guein (BCG) plus Lipopolysaccharide(LPS) were used to induce immunologic liver-injury model in mice. The activities of ALT and AST in the serum and liver were measured. Results:The polysaccharide from kiangsinensis could significantly reduce the activities of ALT and AST in the serum but increase them in the liver of mice with immunologic liver-injury.Conclusion:Polysaccharide from kiangsinensis has protective effect on the Immunologic Liver-injury in mice.