白塞综合征64例分析

Clinical analysis of 64 patients with Behcet's syndrome

目的探讨辽宁籍白塞综合征患者的特点。方法对2002-2005年64例辽宁籍白塞综合征患者的临床资料进行回顾性分析,并与不同国家及中国不同地区的研究结果进行比较。结果64例患者中男女之比为1∶1．2,发病年龄多见20～39岁。口腔溃疡的发生率为100％,生殖器溃疡为70．3％,眼部损害为46．9％,皮肤损害为81．3％,皮肤针刺反应阳性为70．3％,关节受累为43．8％,肾受累为35．9％,神经系统受累为25．0％,胃肠道受累为18．8％,血管受累为4．7％,心脏受累为1．6％,附睾炎为1．6％,有反复口腔溃疡家族史的为12．5％。女性结节性红斑及关节受累较男性多见(分别为P＜0．05),男性胃肠道受累多于女性(P＜0．05)。实验室检查中外周血白细胞增高的占21．9％,尿蛋白增高为15．6％,尿红细胞增高为21．9％,血细胞沉降率增快为44．0％,血IgG增高为19．2％,IgA增高为19．2％,IgM增高为10．6％,C3降低为10．6％,C4降低为8．5％,抗ANA抗体阳性为7．1％,抗ds-DNA抗体阳性为14．3％,抗ENA抗体阳性为9．5％,HLA-B*51等位基因阳性为30．0％。结论白塞综合征某些临床表现的发生率可能因地域的不同存在着差异。

Objective To investigate the clinical features of patients with Behcefs syndrome in Liaoning province. Methods The clinical data of 64 patients with Behcet＇s syndrome seen in Liaoning province between 2002 and 2005 were retrospectively analyzed and compared with those seen in other countries and other areas in China. Results The male-to-female ratio in the patients was 1：1.2, the age of onset of most patients was found to be between 20-39 years. Of the patients, 100% had oral ulcers, 70.3% had genital ulcers, 46.9% had ocular lesions, 81.3% had skin lesions, 70.3% had positive pathergy reaction, and 12.5% had family histories. The frequency of joint involvement was 43.8%, renal involvement 35.9%, neurologic involvement 25.0%, gastrointestinal involvement 18.8%, vascular involvement 4.7%, cardiac involvement 1.6%, and epididymitis 1.6%. Erythema nodosum and joint involvement were more frequent in the females than in the males （ both P 〈 0.05 ）, while gastrointestinal involvement was more frequent in the males than in the females （ P 〈 0.05 ）. Laboratory findings showed that the frequency of increased peripheral blood leukocytes was 21.9%, proteinuria 15.6%, hematuria 21.9%, elevated erythrocyte sedimentation rate 44%, elevated serum IgG, 21.9%, elevated serum IgA 19.2%, and elevated serum IgM 10.6%. The frequencies of decrease of serum C3 and C4 levels were 10.6% and 8.5%, respectively. Also, 7.1% of the patients were positive for ANA, 14.3% for ds-DNA antibody, 9.5% for ENA antibody, and 30.0% for HLA-B＊51 alleles. Conclusion The incidences of some clinical manifestations of Behcet＇s syndrome might be different in different geographical areas.