银屑病患者生活质量调查

The investigation of life quality in patients with psoriasis

目的:研究银屑病对患者生活质量的影响及皮肤病生活质量指数(DLQI)作为判断银屑病病情及疗效新指标的可信性。方法:采用DLQI研究银屑病患者治疗前、后的生活质量及其影响因素,并与传统的银屑病皮损面积和严重度指数(PASI)进行比较。结果:女性患者的DLQI评分明显高于男性,未婚者的DLQI评分高于已婚者,面部受累者的DLQI评分高于面部未受累者(P<0.05)。DLQI和PASI评分呈显著正相关(r=0.633,P<0.001)。治疗后随着临床病情的改善,PASI和DLQI评分均显著下降,且DLQI改善率和PASI改善率呈显著正相关(r=0.722,P<0.001)。结论:银屑病对患者生活质量的影响较大,DLQI可作为判断银屑病病情及疗效的新指标。

Objective： To study the effect of psoriasis on the patients life quality and to evaluate the reliability of dermatology life quality index（DLQI） as a new severity and therapeutic index of psoriasis. Methods： Compared with psoriasis area and severity index （PASI）, DLQI was used to evaluate the life quality in the patients with psoriasis before and after treatment and its affecting factors. Results： The DLQI scores were significantly higher in females than those in males. The scores were also significantly higher in the singlehood patients or the face-involved patients than those in married or the patients with no face lesion respectively （P〈0.05）. There was a significantly positive correlation between PASI and DLQI scores （r=0.633,P〈 0.001）. Both PASI and DLQI decreased with clinical improvement after treatment. There was also a significantly positive correlation of the response rate between in PASI and DLQI scores （r= 0.722, P〈 0.001）. Conclusion： Psoriasis has marked effect on patients life quality and DLQI score can be a new severity and therapeutic index of psoriasis.