窄谱中波紫外线治疗早期蕈样肉芽肿9例疗效观察

Clinical observation of narrowband UVB phototherapy in early-stage mycosis fungoides

目的:观察窄谱中波紫外线(NB-UVB)治疗早期蕈样肉芽肿的疗效及不良反应。方法:使用NB-UVB照射治疗早期蕈样肉芽肿患者9例,初始照射剂量均定为0.5J/cm2。结果:9例患者中完全缓解5例,部分缓解2例,好转2例,有效率为78%。平均照射次数22次,平均累积照射剂量31.09J/cm2。不良反应主要为轻度红斑和瘙痒,其发生率为33%。结论:NB-UVB照射治疗早期蕈样肉芽肿疗效好,不良反应少,操作简便易行,为早期蕈样肉芽肿的治疗提供了一种有效的方法。

Objective： To observe the efficacy and adverse reaction of narrowband UVB（NB-UVB） in the treatment of patients with early-stage mycosis fungoides. Methods： Nine patients were treated by NB-UVB radiation using the protocol provided by the instrument. Results： Five patients had a complete remission, two patients had a partial response, and two patients had improvement. The response rate was 78%. On the average seances of radiation were twenty-two. The mean accumulated radiation dose was 31.09 J/cm^2. The major side effects were mild erythema and pruritus, its incidence was 33%. Conclusion： NB-UVB therapy for patients with early-stage mycosis fungoides is an effective, safe and easily administered treatment modality.