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PGC-1α与肥胖 被引量:10

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出处 《现代医学》 2006年第3期204-206,共3页 Modern Medical Journal
基金 国家自然科学基金项目(30570876)
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参考文献21

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  • 2PUIGSERVER P,WU Z,PARK C W,et al.Peroxisome proliterator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha):transcriptional coactivator and metabolic regulator[J].Endocr Rev,2003,24(1):78-90.
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  • 5ST-PIERRE J,LIN J,KRAUSS S,et al.Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta(PGC-1alpha and PGC-1beta) in muscle cells[J].J Biol Chem,2003,278(29):50047-50052.
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  • 7YAMAMOTO T,SHIMANO H,NAKAGAWA Y,et al.SREBP-1 interacts with hepatocyte nuclear factor-4α and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes[J].J Biol Chem,2004,279(13):12027-12035.
  • 8LIU J,WU P H,JATT P T,et al.Defects in adaptive energy metabolism with CNS-Linked hyperactivity in PGC-1α null mice[J].Cell,2004,119:121-135.
  • 9NEDERGARD J,GOLOZOUBOVA V,MATTHIAS A,et al.UCP1:the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency[J].Biochim Biophys,2001,1504(1):82-106.
  • 10PRPIC V,WATSON P M,FRAMPTON I C,et al.Adaptive changes in adipocyte gene expression differ in AKR/J and SWR/J mice during diet-induced obesity[J].J Nutr,2002,132(1):3325-3332.

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