口腔黏膜下纤维性变及其癌变组织中端粒酶逆转录酶表达

Expression of human telomerase reverse transcriptase in oral submucous fibrosis and carcinogenesis of oral submucous fibrosis

目的:探讨人端粒酶逆转录酶(hTERT)在口腔黏膜下纤维性变(OSF)癌变过程中的作用。方法:用免疫组织化学SP法检测10例正常口腔黏膜组织,46例OSF组织,14例OSF癌变组织以及10例相邻非癌变OSF组织中hTERT表达情况。结果:正常口腔黏膜组织上皮中无hTERT阳性表达,OSF癌变组织中hTERT阳性表达率(12/14)明显高于OSF组(7/46)(P<0.005),相邻非癌变OSF组织中hTERT阳性表达率(7/10)明显高于普通OSF组(7/46)(P<0.005)。结论:hTERT蛋白过度表达在OSF癌变过程中具有重要作用。

Objective：To investigate the role of human telomerase reverse transeriptase （hTERT） in carcinogenesis of oral submucous fibrosis（OSF）. Methods ：The expression of hTERT was examined by immunohistochemical SP method in 10 cases of normal oral mucosa, 46 cases of OSF, 14 of carcinogenesis of OSF and 10 of adjacent non-cancerous OSF tissue. Results：The expression of hTERT was negative in normal oral muscosal epithelium. The frequency of hTERT positive expression was higher in carcinogenesis lesions of OSF （12/14） than those in OSF（ 7/46 ） （ P〈0.005 ）, and the frequency of hTERT expression was higher in adjacent non-cancerous OSF tissue （7/10） than that in OSF（7/46） （P〈0.005 ）. Conclusions： hTERT over expression may play an important role in the carcinogenesis of OSF.