摘要
目的探讨标记物18F-FDDNP在脑断层扫描(PET)显像中诊断阿尔茨海默病(AD)的价值。方法分别对7例AD患者(AD组)、6例血管性痴呆(VaD)患者(VaD组)及6例智能正常老年对照者(NC,NC组)进行18F-FDDNP脑PET显像,受试者分别在药物注射后5 min2、5 min和45 min采集图像。结果AD患者3个时段放射性清除情况与其他2组图像有明显的不同。药物注射45 min后脑内放射性清除率较VaD组、NC组明显减低。结论18F-FDDNP脑PET显像是诊断AD的一个有效的影像学指标。
Objective To evaluate the role of brain positron emission tomography（PET） with 2-（ 1-（6-[（2-[^18F ] fluoroethyl ） （ methyl ） amino ] -2- naphthyl ） ethylidene） malononitrile （^18 F- FDDNP ） in the diagnosis of Alzheimer＇s disease （AD）.Methods Seven Alzheimer＇s disease（AD） patients,6 vascular dementia（VD） patients and 6 normal controls（NC） were assessed with brain PET with^18F-FDDNP. Images were obtained at 5 min, 25 min and 45 min after^18F-FDDNP administration. Results Compared with VD and NC, the AD group showed significant difference in clearance rate ofIs F-FDDNP and images at three stages. The clearance rate in AD group statistically declined at 45 min after the injection of ^18F-FDDNP, especially in areas of cortex known to contain large amount of amyloid deposits in AD. Conclusion These data indicate the usefulness of brain PET with^18F-FDDNP in vivo imaging for early diagnosis of AD.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2006年第6期377-379,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
