高聚生对胃腺癌患者TDLN细胞抗肿瘤活性的影响

The Effect of Highly Agglutinative Staphylococcin on antitumor reactivity of TDLN cells of gastric carcinoma

目的:观察高聚生(HAS)对胃腺癌患者肿瘤引流淋巴结(TDLN)细胞抗肿瘤活性的影响。方法:40例胃腺癌患者随机分为实验组和对照组,实验组于术前1周静脉给予高聚生。术中取肿瘤引流区淋巴结,分离TDLN细胞,比较两组TDLN细胞对胃腺癌细胞系KATO3和黑色素瘤细胞系A375的杀伤作用。结果:实验组对KATO3细胞系的杀伤作用明显优于对照组;而对A375细胞,各组细胞的杀伤作用无明显差异。结论:高聚生可增强胃腺癌患者TDLN细胞的杀伤作用。

Objective： To explore the effect of Highly Agglutinative Staphylococcin （HAS） on anti-neoplastic activity of tumor-draining lymph node （TDLN） cells in patients with gastric carcinoma. Methods： Forty patients with gastric carcinoma were randomized into the experimental group （HAS group） and the controls. The patients in the experimental group were injected with HAS for 7 successive days before surgery, The TDLN were removed from patients during the operation. TDLN cells were isolated and purified from local lymph nodes of the patients. The cytotoxic activity of TDLN cells to gastric adenocarcinoma cell line KATO3 and the human melanoma cell line A375 were compared in the tWO groups. Results： The cytotoxicity of TDLN cells to KATO3 cells in the experimental group was significantly stronger than that of TDLN cells in the control group. In contrast, for A375 cells, cytotoxic activities of TDLN cells in the two groups showed no overt difference. Conclusion： The antineoplastic activity of TDLN cells can be enhanced significantly by HAS.