摘要
目的：分析手术前血清CEA、CA19-9和CA50在结直肠癌患者中的表达情况，研究其在不同肿瘤临床分期中的表达差异，及其与临床病理学特点的相关性。方法：回顾分析2000年1月～2004年9月于肿瘤医院接受治疗的结直肠肿瘤病例1340例，术前采用放射免疫法测定血清CEA、CA19-9和CA50水平，术后综合术前影像学检查、术中探查结果和术后组织病理学检测进行临床分期，应用SPSS12．0统计软件进行相关性分析。结果：在1340例患者中，有59例为外院手术后复发或者转移的患者，另外的1281例患者均为初治病例。其中结直肠癌患者1327例。CEA、CA19-9和CA50检测阳性率分别为25．9％、22．3％和22．8％，同手术性质（根治性／姑息性）和脉管侵犯等临床病理指标相关。CEA、CA19-9和CA50在不同肿瘤分期中表达差异显著，主要在D期患者和复发转移患者中出现高阳性率。CEA在粘液腺癌和腺癌组织中表达差异显著。三个指标的表达和患者性别无关。结论：CEA、CA19-9及CA50和肿瘤的临床分期密切相关，其阳性表达提示合并淋巴结或者脏器转移可能，是预后不良指标。
Objective：To analyze the expression of preoperative CEA, CA19-9 and CA.50 in the patients with colorectal neoplasm and explore its correlation with some clinico-pathological characteristics. Methods： 1 340 cases of colorectal neoplasm who received operation from Jan 2000 to Sep 2004 were collected and serum CEA, CA19-9, CA50 were tested by radioimmunal techniques. The correlation between expression of these tumor markers and clinico-pathological characteristics were analyzed. Statistic analysis was operated with SPSS 12. 0 software package. Results：59 cases got treatments for recurrences, and 1 281 cases were operated for the primary diseases in our hospital with 1 327 cases of carcinoma. The positive rate of CEA, CA19-9 and CAS0 was 25.9% ,22. 3% and 22. 8% respectively. The expression showed correlation with some clinico-pathological characters such as features of operation （ curative or palliative） and vascular invasion. Significant differences between Dukes＇ stages were found with high positive rate in the groups of Dukes＇ D stage and/or with recurrence and metastasis. CEA was highly expressed in the mucinous adenocareinoma compared with adenocareinoma. These markers had no relationship with sex of patients. Conclusion：the expression of CEA,CA19-9 and CAS0 has close correlation with clinico-pathological stage. They are negative prognostic factors of colorectal carcinoma.
出处
《临床肿瘤学杂志》
CAS
2006年第5期326-330,共5页
Chinese Clinical Oncology
