血管内皮生长因子在非小细胞肺癌中的表达及意义

Expression and significance of serum vascular endothelial growth factor in patients with non-small cell lung cancer

目的研究血清血管内皮生长因子(serumvascularendothelialgrowthfactor,sVEGF)与非小细胞肺癌(NSCLC)临床病理特征的关系,探讨其对NSCLC早期诊断及预后评价的意义。方法用酶联免疫法检测70例初治NSCLC患者和20例健康献血者sVEGF的含量。结果NSCLC患者sVEGF平均含量为888.4±131.8pg/ml,明显高于正常对照组的251.3±48.6pg/ml(P<0.01)。不同临床分期间sVEGF含量有显著性差异(P<0.01)。随着临床分期的进展,sVEGF含量呈上升趋势。结论sVEGF与NSCLC的发生、发展密切相关,可作为肺癌早期诊断和预后评价的一个可靠参考指标。

Objective：To study the relationship between the serum vascular endothelial growth factor （sVEGF） and the clinical characteristics of the patients with non-small cell lung cancer （ NSCLC）, and to research the significance of sVEGF in the early diagnosis and prognosis. Methods：The sVEGF was measured by enzyme-linked immunosorbent assay in 70 patients with NSCLC and 20 healthy subjects. Results：The sVEGF of patients with NSCLC was 888.4 ± 131.8 pg/ml,and the sVEGF of control group was 251.3 ± 48. 6 pg/ml. The sVEGF of patients with NSCLC was significantly higher than that of control group（ P 〈 0. 01 ）. The sVEGF of patients in different clinical stages was significant difference （ P 〈 0. 01 ）, and it increased with the progression of clinical stages. Condusion： The sVEGF has an important relationship with NSCLC,it may be a reliable marker for early diagnosis and prognosis.