期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Preparation and Characterization of Copolymer Micelles Formed by Poly(ethylene glycol)-Polylactide Block Copolymers as Novel Drug Carriers

Preparation and Characterization of Copolymer Micelles Formed by Poly(ethylene glycol)-Polylactide Block Copolymers as Novel Drug Carriers
下载PDF
导出
摘要 Diblock copolymer poly(ethylene glycol) methyl ether–polylactide (MePEG–PLA) micelles were prepared by dialysis against water. Indomethacin (IMC) as a model drug was entrapped into the micelles by dialysis method. The critical micelle concentration (CMC) of the prepared micelles in distilled water investigated by fluorescence spectroscopy was 0.0051 mg/mL which is lower than that of common low molecular weight surfactants. The diameters of MePEGPLA micelles and IMC loaded MePEGPLA micelles in a number-averaged scale measured by dynamic light scattering were 52.4 and 53.7 nm respectively. The observation with transmission electron microscope and scanning electron microscope showed that the appearance of MePEGPLA micelles was in a spherical shape. The content of IMC incorporated in the core portion of the micelles was 18% (ω). The effects of the synthesis method of the copolymer on the polydispersity of the micelles and the yield of the micelles formation were discussed. Diblock copolymer poly（ethylene glycol） methyl ether-polylactide （MePEG-PLA） micelles were prepared by dialysis against water. Indomethacin （IMC） as a model drug was entrapped into the micelles by dialysis method. The critical micelle concentration （CMC） of the prepared micelles in distilled water investigated by fluorescence spectroscopy was 0.0051 mg/mL which is lower than that of common low molecular weight surfactants. The diameters of MePEG-PLA micelles and IMC loaded MePEG-PLA micelles in a number-averaged scale measured by dynamic light scattering were 52.4 and 53.7 nm respectively. The observation with transmission electron microscope and scanning electron microscope showed that the appearance of MePEG-PLA micelles was in a spherical shape. The content of IMC incorporated in the core portion of the micelles was 18% （ω）. The effects of the synthesis method of the copolymer on the polydispersity of the micelles and the yield of the micelles formation were discussed.
作者 姜维 王运东 甘泉 张建铮 赵秀文 费维扬 贝建中 王身国
机构地区 State Key Laboratory of Chemical Engineering School of Chemical Engineering Institute of Chemistry
出处 《过程工程学报》 EI CAS CSCD 北大核心 2006年第2期289-295,共7页 The Chinese Journal of Process Engineering
基金 National Natural Science Foundation of China (No.29836130)
关键词 聚乙二醇 聚交酯 嵌段共聚 聚合物 药物担体 poly（ethylene glycol） polylactide block copolymer polymer micelle drug carrier
分类号 R944.1 [医药卫生—药剂学]
  • 相关文献

参考文献32

  • 1Jain R K.Delivery of Molecular and Cellular Medicine to Solid Tumors[J].Adv.Drug Deliv.Rev,1997,26(2/3):71-90.
  • 2Adams M L,Lavasanifar A,Kwon G S.MINIREVIEW Amphiphilic Block Copolymers for Drug Delivery[J].J.Pharm.Sci,2003,92(7):1343-1355.
  • 3Lee J H,Lee H B,Andrade J D.Blood Compatability of Polyethylene Oxide Surfaces[J].Prog.Polym.Sci,1995,20(6):1043-1079.
  • 4Bailey F E,Koleske J Y.Poly(ethylene oxide)[M].New York:Academic Press,1976.29.
  • 5Trubetskoy V S,Torchilin V P.Use of Polyoxyethylene-Lipid Conjugates as Long-circulating Carriers for Delivery of Therapeutic and Diagnostic Agents[J].Adv.Drug Deliv.Rev,1995,16(2/3):311-320.
  • 6Zalipsky S,Harris J M.Introduction to Chemistry and Biological Applications of Poly(ethylene glycol)[A].Harris J M,Zalipsky S.Poly(ethylene glycol) Chemistry and Biological Applications,ACS Symposium Series 680[C].Washington,DC:American Chemical Society,1997.1-13.
  • 7Yamaoka T,Tabata Y,Ikada Y.Distribution and Tissue Uptake of Poly(ethylene glycol) with Different Molecular Weights after Intravenous Administration to Mice[J].J.Pharm.Sci,1994,83(4):601-606.
  • 8Wang P,Tan K L,Kang E T.Surface Modification of Poly (tetrafluoroethylene) Films via Grafting of Poly(ethylene oxide) for Reduction in Protein Adsorption[J].J.Biomater.Sci.Polym.Ed,2000,11(2):169-186.
  • 9Jeon S I,Lee J H,Andrade J D,et al.Protein-surface Interactions in the Presence of Polyethylene Oxide:I.Simplified Theory[J].J.Colloid Interface Sci,1991,142(1):149-158.
  • 10Cammas S,Suzuki K,Sone C,et al.Thermo-responsive Polymer Nanoparticles with a Core-Shell Micelle Structure as Site-specific Drug Carriers[J].J.Controlled Release,1997,48(2/3):157-164.
过程工程学报
2006年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部