自然流产的免疫学因素分析与探讨

Analysis and investigation on immune factor of spontaneous abortion.

目的为探讨自然流产与免疫学因素的关系。方法采用酶联免疫吸咐试验(ELISA)对612例自然流产妇女进行血清抗子宫内膜抗体(EMAb)、抗心磷脂抗体(ACA)、抗人绒毛膜促性腺激素抗体(HCGAb)测定。结果流产组132例HCGAb阳性,阳性率为21.5%;150例EMAb阳性,阳性率为24.5%;184例ACA阳性,阳性率为30.1%;63.2%的患者体内有两种以上抗体并存,与对照组比较,有高度显著性差异。结论抗心磷脂抗体、抗人绒毛膜促性腺激素抗体、抗子宫内膜抗体是造成自然流产的不可忽视的免疫学因素。

Objective： To explore the relationship between spontaneous abortion and immune factor. Methods： Anti -HCG antibody （HCGAb）, anti- endometrial antibody （EMAb）, anti- cardiolipm antibody （ACA） of 612 cases of spontaneous abortion women were determined by using enzyme linked immunosorbent assay （ELISA）. Results ： Postive rate of HCGAb, EMAb ang ACA was 21.5%, 24. 5%, 30. 1% and there were two antibodtes about 63.2% in spontaneous abortion women. Conclusion： Anti - HCG antibodies, anti - endometrial antibodies and anti - cardiolipm antibodies were important immune factor of spontaneous abortion.