法氏囊提取液对新城疫活疫苗免疫效力的影响

Affect of chicken bursal extracts on immune efficacy of live Newcastle disease virus vaccine

本文对鸡法氏囊提取液与ND活疫苗的使用方法进行了分析。通过血凝抑制抗体滴度的测定结果表明,预先接种鸡法氏囊提取液时,经肌肉注射、口服和点眼滴鼻接种方式均能提高ND疫苗免疫鸡的抗体产生能力,且经肌肉注射法最佳。但是,在整个试验期间,法氏囊提取液只能增强鸡群对ND活疫苗的早期免疫应答,而法氏囊提取液与ND活疫苗同时使用时更能刺激免疫鸡群的早期抗体产生水平。

In this paper, usage of chicken bursal extracts and live Newcastle disease virus （NDV） vaccine were analyzed by titration of the hemagglutination inhibition antibody against NDV.The results showed that when chickens were inoculated with bursal extracts prior to live NDV vaccine, the intramuscular injection, oral administration and eye-nose drop method could prompt antibody production ability of chickens, but the muscle injection method was the best one. However, at the whole experimental period, the bursal extracts only enhanced earlier immune response of chickens to live NDV vaccine, and usage of the extracts and live vaccine at the same time might accelerate earlier specific antibody level more.