药源性血糖异常1590例文献分析

Literature Analysis of 1590 Cases of Drug-induce Pathoglycemia

目的：探讨药物引起血糖异常的特点及一般规律.方法：检索1994年1月～2005年6月国内医药卫生期刊报道的药源性血糖异常1 590例,并进行统计、分析.结果：引起血糖异常的药物种类主要以激素及其相关用药（17种）、抗微生物药（13种）、中枢神经系统药（8种）为主,其中位居前2位的分别是格列本脲（699例）、极化液（242例）;临床表现以血糖降低为多见.结论：临床工作者应重视药物引起血糖异常的现象,在用药时应加强对患者的血糖监测,确保用药安全.

OBJECTIVE：To disscuss the general regularity and characteristics of drug- induced pathoglycemia.METHODS： 1 590 cases of drug - induced pathoglycemia reported in internal medical journals published from Jan. 1994 to Jun .2005 were collected and analyzed.RESULTS： The drugs that induced pathoglycemia were included chiefly hormone and relate drugs（17 species）, antimicrobial drugs（ 13 species） and central nervous system drugs（8 species）, glibenclamide was reported mostly（699 cases） and the next was polarized solution（242 cases）.The most clinical manifestation was the decrease of blood sugar.CONC- LUSIONS：Clinician should take care of drug- induced pathoglycemia and strengthen the monitor of the level of patient＇s blood suguar in use the drug, to make sure of the safety of the drug.