摘要
目的:研究白藜芦醇抗衰老的免疫学机制,开发白藜芦醇新的临床用途。方法:建立小鼠衰老模型,然后用白藜芦醇干预,观察其对小鼠衰老现象的影响作用。结果:白藜芦醇干预组小鼠血清超氧化物歧化酶(SOD)含量升高,血清丙二醛(MDA)含量下降;该组胸腺指数升高而脾脏指数无明显改变;同时其血清中CD4+细胞数量不改变,而CD8+细胞数量升高,CD8+细胞与CD4+细胞比值降低;还能使血清中IL-6、IL-8的含量降低。结论:白藜芦醇具有一定的抗衰老作用。
Objective ： To research resveratrol＇ s mechanism of immunity in anti-aging and explore the new clinical use of resveratrol. Methods ： The sub acute aging model was made by continuous subcutaneous injection of D galactose to mice inducing reactive oxygen species （ROS）. Meanwhile, the resveratrol was given and its effect on anti-aging was observed. Results： The resveratrol could in crease the content of SOD and decrease the content of MDA in serum. There was no change in spleen index, but thymus index increased obvionsly. There was no change in the quantity of CD4^＋ , but the quantity of CD8^＋ increased and the ratio of CD^＋/CD8^＋ was decreased. The serum IL-6 and IL-8 level were decreased obviously. Conclusion： The resveratrol possessed the function to anti-aging and the applications foreground in anyi-aging.
出处
《中药材》
CAS
CSCD
北大核心
2006年第5期464-467,共4页
Journal of Chinese Medicinal Materials
关键词
白藜芦醇
抗衰老
免疫
机制
Resveratrol
Anti-aging
Immunity
mechanism
