健康人与冠心病人心室复极时间的昼夜节律对比研究

Comparison of ventricular repolarization time and its circadian rhythm in health subjects and patients with coronary artery disease

目的探讨冠心病和冠心病高危因素对心室复极时间及其昼夜节律的影响。方法观察冠心病、冠心病高危因素病人、健康人的心室复极时间昼夜分布曲线,并进行对比分析。结果各组均显示J-T间期呈夜长昼短,午后稍回升的节律,经心率校正后,这种节律变小,冠心病人则消失。结论经心率校正后,心室复极时间本身存在夜长昼短节律。冠心病人的心室复极时间昼夜变化消失,与心肌缺血、自主神经病变、心脏结构重构等相关,可能是其易发生室性心律失常的原因。

Objective To investigate effect of coronary artery disease and risks of coronary artery disease on ventricular repolarization time and its circadian rhythm. Methods Circadian rhythm of ventricular repolarization time in healthy subjects, individuals with risks of coronary artery disease and patients with coronary artery disease were analyzed. Results Ventricular rcpolarization time in each group was long at night and short by day, which prolonged lightly in afternoon. Circadian variation disappeared in patients with coronary artery disease, but preserved in healthy subjects and individuals with risks of coronary artery disease, when ventricular repolarization time was corrected by heart rate. Conclusion Circadian rhythm of ventricular rcpolarization time corrected by heart rate disappears in patients with coronary artery disease. This may be related with myocardial isehemia, autonomic nerve dysfunction and cardiac remodeling.