中国汉族人群系统性红斑狼疮HLA-DQ基因多态性的Meta分析

A meta-analysis of the association of HLA-DQ polymorphism and systemic lupus erythematosus in Chinese population

目的综合评价中国汉族人群HLA-DQ基因多态性与系统性红斑狼疮(SLE)的关联性。方法以系统性红斑狼疮病例组和健康对照组的各HLA-DQ等位基因频数分布的OR值为统计量,全面检索相关文献,应用M eta分析软件包Revm an 4.2,在基因分型水平上,对各研究的结果进行一致性检验和数据合并,并评估发表偏倚。结果等位基因DQA1*0102、DQB1*0601是中国汉族人群SLE患者的危险基因(均P<0.05),它们的合并OR值分别为:1.82,1.95;等位基因DQA1*0301、DQA1*0302、DQA1*0601、DQB1*0301、DQB1*0302、DQB1*0401和DQB1*0503是中国汉族人群SLE患者的保护基因(均P<0.05),它们合并OR值分别为:,0.72,0.43,0.36,0.40,0.39,0.24,0.41。结论中国汉族人群SLE与HLA-DQ的某些等位基因具有关联性,且存在区别于其他人群的特殊性。

Aim To evaluate the relationship between genetic polymorphisms of HLA-DQ and systemic lupus erythematosus in Chinese population. Methods Odds ratios （OR） of HLA-DQ allele distributions in patients with SLE against healthy controls were analysed. All the relevant studies were identified, poor qualified studies excluded and the publication bias was evaluated. The Meta-analysis software, Revman 4.2, was applied for investigating heterogeneity among individual studies and for summarizing all the studies. Results DQA1 ＊ 0102 and DQB1 ＊ 0601 were the risky alleles （all P 〈 0.05 ） in Chinese population,whose pooled OR values were 1.82,1.95. DQA1 ＊ 0301, DQA1 ＊ 0302, DQA1 ＊ 0601, DQB1 ＊ 0301, DQB1 ＊ 0302, DQB1 ＊ 0401 and DQB1 ＊ 0503 were the protective alleles （ all P 〈 0. 05 ）, whose pooled OR values were 0.72,0.43,0.36,0.40,0.39,0.24,0.41 respectively. Conclusions In Chinese population, some HLA-DQ alleles are associated with the SLE,and these associations are different from those in other populations.