磷酸二酯酶抑制剂的药理及临床应用进展

Pharmacology and application progress of the phosphodiesterase inhibitor

查阅近年来国内有关磷酸二酯酶抑制剂的文献资料。了解磷酸二酯酶抑制剂近年来的临床应用情况,并对其作用机制进行分析,为进一步的开发应用提供依据。磷酸二酯酶抑制剂因磷酸二酯酶同功酶种类的不同,分布的不同及选择性的不同等诸多原因,呈现不同的临床作用。选择性的磷酸二酯酶抑制剂可治疗多种疾病,已成为应用及开发强心药、血管舒张药、平滑肌舒张药、抗哮喘药、抗抑郁药等新热点。

The authors have done the research by consulting the relative domestic phosphodiesterase inhibitor literature published in recent years. Attempts have been made to know the statws quoof the phosphodiesterase inhibitor clinical practice in recent years. An analysis of its functional mechanism has been made ,for further development. The researches show that phosphodiesterase inhibitor has different functions in clinical practice because of phosphodiesterase isoenzyme type difference, distribution difference and selective difference, etc. Selective phosphodiesterase inhibitor may be used to treat many kinds of diseases, and has been the hot spot in being applied to developing cardiac agents, vasodilatation medicine, muscle-smoothing diastole medicine, aotiasthmatic medicine, anti- despondent medicine, etc.