米非司酮合并米索前列醇终止10～16周妊娠的疗效

Termination of 10-16 week's gestation with mifepristone plus misoprostol

目的：观察口服米非司酮合并米索前列醇终止１０～１６ｗｋ妊娠的临床疗效。方法：１７５例妊娠１０～１６ｗｋ妇女用２种不同剂量米非司酮（组Ⅰ２５ｍｇｂｉｄ×３ｄ，总量１５０ｍｇ；组Ⅱ２００ｍｇ单次用药），合并米索前列醇（最大剂量不超过１．６ｍｇ）口服。结果：２组流产成功率分别为８９％和８４％，Ｐ＞０．０５。组Ⅰ胎儿排出时间（７ｈ）明显短于组Ⅱ（９ｈ），Ｐ＜０．０１。组Ⅰ米索前列醇用量（０．７ｍｇ）明显少于组Ⅱ（１．０ｍｇ），Ｐ＜０．０１。结论：口服米非司酮合并米索前列醇终止１０～１６ｗｋ妊娠是安全有效的；给药方法以米非司酮小剂量多次给药法更可取。

AIM:To study the abortifacient effects of mifepristone combined with misoprostol in the 10-16 week's gestation. METHODS: One hundred and seventy-five women with 10-16 week's gestation were divided into two groups: 92 pregnant women (group Ⅰ) received mifepristone 25 mg bid for 3 d and 83 pregnant women (group Ⅱ) received a single dose of mifepristone 200 mg, then all women followed by several doses of misoprostol (total dose<1.6 mg). RESULTS: The rate of abortient success in group Ⅰ and group Ⅱ were 89% and 84 %, respectively (P>0.05). The interval between misoprostol administration and gestation sac expulsion was significantly shorter in group Ⅰ than group Ⅱ (7h vs 9h) P<0.01 . The average dose of misoprostol was significantly less in group Ⅰ than in groupⅡ (0.7 mg vs 1.0mg, P<0.01). CONCLUSION: The combination of po mifepristone and misoprostol is a safe and effective method in the management of 10-16 week's gestation abortion, and taking mifepristone in small dose for several times seems more effective.