服用抗精神病药物的老年人与成年人心电图比较

Elctrocardiographic comparison between elderly and adult patients after antipsychotics

目的：观察老年与成年精神病人服用抗精神病药物后的心电图（ＥＣＧ）改变。方法：８４例老年精神病病人（男性３５，女性４９例，年龄６３±ｓ３ａ）与１００例成年精神病病人（男性５０例，女性５０例，年龄４０±１０ａ），服用抗精神病药物前及服２ｍｏ以上的首次ＥＣＧ资料进行比较。抗精神病药包括吩噻嗪类、丁酰苯类及三环类抗抑郁剂和抗躁狂药等。结果：８４例老年病人中ＥＣＧ异常６３例（７５％），１００例成年人中ＥＣＧ异常４６例（４６％）（Ｐ＜０．０５）。结论：由于老年人服抗精神病药后易发生ＥＣＧ异常，因此开始剂量宜低，增量要小，严密监测心脏功能。

AIM: To compare the electrocardiographic (ECG) changes between elderly and adult patients. METHODS: The ECG data of premedications and first ECG data of more than 2 mo postmedications were compared between 84 elderly patients (M 35, F 49,age 63±s 3 a) and 100 adult patients (M 50, F 50, age 40±10 a). RESULTS: The ECG abnormalities were found in 63 of 84 elderly patients (75%) and 46 of 100 adult patients(46%), (P<0.05). CONCLUSION: In treating elderly patients, the initial dose of antipsychotics should be low and increased gradually and the cardiac function should be closely monitered.