维拉帕米与山莨菪碱治疗肾绞痛的比较

Verapamil vs anisodamine in treating renal colic

目的：比较维拉帕米与山莨菪碱治疗肾绞痛的疗效。方法：１５３例肾绞痛病人随机分为３组。Ａ组５４例（男性３５例，女性１９例；年龄３５±ｓ９ａ）采用维拉帕米２０ｍｇ；Ｂ组４８例（男性３０例，女性１８例；年龄３４±７旬采用维拉帕米８０ｍｇ；Ｃ组５１例（男性３２例，女性１９例；年龄３７±１０ａ）采用山莨菪碱２０ｍｇ。以上３个药分别加入５％葡萄糖液２５０ｍＬ，静脉滴注，且于１ｈ滴完。结果：Ａ组总有效率８９％，Ｂ组９２％，Ｃ组７３％；Ａ，Ｂ２组分别与Ｃ组比较，差别均有显著意义（Ｐ＜０．０５）。Ｂ组显效率明显优于Ａ或Ｃ组（Ｐ＜０．０５）。结论：Ｂ（维拉帕米８０ｍｇ）组疗效最佳。

AIM: To compare the efficacy of verapamil in treating renal colic with that of anisodamine. METHODS: 153 patients with renal colic were randomly divided into 3 groups. (A) 54 patients (M 35, F 19; age 35±s 9 a) received verapamil 20 mg+5% glucose 250 mL, iv, drip, for 1 h. (B) 48 patients (M 30, F 18; age 34±7 a) received verapamil 80 mg+ 5% glucose 250 mL, iv, drip, for 1 h. (C) 51 patients (M 32, F 19, age 37±10 a) received anisodamine 20 mg + 5% glucose 250 mL, iv, drip,for 1 h. RESULTS: The total response rates in group A (89%) and group B (92%) were better than that of group C (73%) (P<0.05). The marked response rate in group B was better than that of group A and group C (P<0.05). CONCLUSION: The efficacy of verapmil (80 mg) group was the best.