摘要
The major metabolites of ginsenoside-Rb1 in rats urine were described.Urine samples were collected before and after 24 h of single oral administration of 150 mg and intravenous administration of 60 mg Rb1 to four rats,respectively.The samples were purified by SPE column and then were analyzed by liquid chromatography-ESI-mass spectrometry for potential metabolites.Parent drug and its fourteen metabolites were identified in rat urine based on the comparison of total ion chromatograms of the blank with the metabolic urine as well as mass spectra.Its main metabolic pathways and possible structures are analyzed in detail.
The major metabolites of ginsenoside-Rb1 in rats urine were described. Urine samples were collected before and after 24 h of single oral administration of 150 mg and intravenous administration of 60 mg Rb1 to four rats, respectively. The samples were purified by SPE column and then were analyzed by liquid chromatography-ESI-mass spectrometry for potential metabolites. Parent drug and its fourteen metabolites were identified in rat urine based on the comparison of total ion chromatograms of the blank with the metabolic urine as well as mass spectra. Its main metabolic pathways and possible structures are analyzed in detail.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2006年第6期1042-1044,共3页
Chemical Journal of Chinese Universities
基金
国家'八六三'计划(批准号:2002AA2Z341B)资助
