2-氨基-1,3,4-噻二唑合成新方法

A New Method for Synthesis of 2-Amino-1,3,4-Thiadiazole

首次以草酸为原料在盐酸催化下一步合成了2-氨基-1,3,4-噻二唑,产品的纯度达到99%(HPLC)以上,并通过IR1、3C NMR、高分辨MS等手段对其结构进行了表征.实验结果表明,该合成路线具有反应条件温和、收率高、操作简单、对环境安全友好等特点.与甲酸相比,草酸价格更便宜,这种方法不仅降低了生产成本,而且易于工业化生产.

2- amino- 1, 3, 4- thiadiazole was synthesized by reaction of aminothiourea with oxalic acid in the presence of hydrochloric acid as catalyst in one step. The purity of the product is higher than 99% （HPLC）. Its structure was characterized by IR,^13C NMR and HRMS. It is testified that the facile synthetic scheme put forward in this work has the characteristics of mild reaction condition, high yield, simple operation and being environmentally-friendly. Compared with formic acid, oxalic acid is cheaper, and the cost is reduced;a scale production can be achieved.