肝脂消合剂对高脂饮食致脂肪肝小鼠组织病理的影响

Effect of Ganzhixiao Mixture on pathological histology of fatty liver mice model induced by high fat diet

目的观察肝脂消合剂对小鼠肝脂肪变性的治疗作用。方法以高脂乳剂塑造小鼠肝高脂的脂肪肝模型,以东宝肝泰片为阳性对照,并观测肝脂消合剂对小鼠的肝组织病理的影响。结果肝脂消合剂能使高脂乳剂所致小鼠脂肪肝肝组织中脂变肝细胞数目明显减少,胞浆内脂滴数目减少或消失,无明显炎细胞坏死或浸润。结论肝脂消合剂具有改善肝脂肪化变性的作用。

Objective To observe treatment effects of Ganzhixiao Mixture on the fatty denaturation of mice liver.Methods Modeled the mice fatty liver by high fat emulsion, compareing with DBGT tablet, and observe the effects of Ganzhixiao Mixture on mice liver pathology histology. Results The number of fatty denaturation liver cells of the fatty-liver model mice induced by high fat emulsion can be significantly reduced by Ganzhixiao Mixture;in the liver cytoplast, the fatty drops reduced or disappeared,and there aren＇t obviously phagocyte necrosis or infiltration. Conclusion Ganzhixiao Mixture is effective in improving the fatty denaturation of liver.